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Related Experiment Videos

An in vivo and post mortem MRI study in multiple sclerosis with pathological correlation.

G Macchi1, R P Cioffi

  • 1Clinica Neurologica Università Cattolica del Sacro Cuore, Roma.

Italian Journal of Neurological Sciences
|December 1, 1992
PubMed
Summary

Magnetic resonance imaging (MRI) of a formalin-fixed brain from a multiple sclerosis (MS) patient revealed lesion distribution similar to histological sections. MRI signal intensity correlated with MS lesion age and histological features.

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Area of Science:

  • Neurology
  • Neuroimaging
  • Pathology

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
  • Assessing lesion age and distribution in MS is crucial for understanding disease progression.
  • Post-mortem analysis offers a unique opportunity to correlate in vivo findings with detailed histopathology.

Observation:

  • A formalin-fixed brain from a young woman with a history of multiple sclerosis (MS) was studied using magnetic resonance imaging (MRI).
  • The patient experienced a relapse before death from pulmonary embolism.
  • Histological and immunocytochemical staining were performed on the left hemisphere for detailed examination.

Findings:

  • Despite fixation reducing relaxation times, MRI provided satisfactory signal and contrast for the fixed brain.

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  • MRI-detected lesion distribution closely matched histological sections.
  • The post-mortem MRI and pathological study identified new lesions, consistent with the patient's clinical course.
  • MRI signal intensity varied with lesion age, correlating with histological features.

    • Implications:

    • Post-mortem MRI of fixed brain tissue is a viable method for studying MS pathology.
    • Comparing pre- and post-mortem MRI scans can help determine the age of MS lesions.
    • MRI signal characteristics can potentially indicate the age and histological nature of MS lesions.