Related Experiment Video
Updated: Jul 21, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Clinical features of the idiopathic long QT syndrome
1Heart Research Follow-up Program, Department of Community and Preventive Medicine, University of Rochester School of Medicine, N.Y.
Abstract:
Long QT syndrome (LQTS) is an infrequently occurring familial disorder in which affected members have electrocardiographic QT interval prolongation and a propensity to syncope and fatal ventricular arrhythmias. This review of the current literature includes discussions of inheritance, clinical presentation, diagnosis, and treatment of LQTS. At present, there are three modalities of treatment for LQTS patients: beta-blockers, pacemakers, and left cervicothoracic sympathetic ganglionectomy. Because the clinical course of LQTS is quite variable, therapy must be individualized for each patient.
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