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Dermatan sulphate in haemodialysis
1Department of Haematology, Charing Cross and Westminster Hospital and Medical School, London, UK.
Lancet (London, England)
|February 8, 1992
Summary
Dermatan sulfate effectively inhibits blood clots in patients undergoing hemodialysis. This antithrombotic agent shows promise as a safer alternative to heparin for preventing thrombosis.
Area of Science:
- Pharmacology
- Hematology
- Nephrology
Background:
- Dermatan sulfate exhibits antithrombotic properties, potentially inhibiting venous thrombi with less bleeding risk than heparin.
- Unlike heparin, which targets antithrombin III, dermatan sulfate selectively inhibits thrombin via heparin co-factor II.
Purpose of the Study:
- To evaluate the efficacy and safety of dermatan sulfate as an anticoagulant and antithrombotic agent.
- To conduct dose-finding studies for dermatan sulfate in patients requiring maintenance hemodialysis.
Main Methods:
- Dose-finding studies were performed.
- The study population comprised patients on maintenance hemodialysis.
Main Results:
- Dermatan sulfate demonstrated effectiveness as an anticoagulant in the studied patient group.
- The agent showed potential for antithrombotic activity.
Conclusions:
- Dermatan sulfate is an effective anticoagulant in patients undergoing maintenance hemodialysis.
- Further research into dermatan sulfate's antithrombotic potential is warranted.
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