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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
HPV-16-related DNA sequences in Kaposi's sarcoma
1Department of Microbiology, New York University School of Medicine, New York.
Lancet (London, England)
|February 29, 1992
Summary
Human papillomavirus (HPV) DNA sequences, particularly HPV-16, were detected in various forms of Kaposi
Area of Science:
- Oncology
- Virology
- Dermatology
Background:
- Kaposi's sarcoma (KS) is disproportionately common in homosexual/bisexual men with acquired immunodeficiency syndrome (AIDS).
- An infectious etiology for AIDS-related KS (AIDS-KS) is hypothesized.
- Human papillomavirus (HPV), specifically HPV-16, is prevalent in homosexual men.
Purpose of the Study:
- To investigate the presence of HPV DNA sequences in Kaposi's sarcoma tissues and cell cultures.
- To determine if HPV-16 is associated with different forms of KS.
Main Methods:
- Polymerase chain reaction (PCR) was employed using primers specific for the HPV-16 E6 region.
- Tumor tissues (n=97) and KS-derived cell cultures were analyzed for HPV-16 DNA fragments.
Main Results:
- HPV-16 homologous DNA sequences were identified in KS lesions from homosexual men with AIDS-KS (11/69).
- Sequences were also found in KS biopsy specimens from HIV-negative homosexual men (3/11) and classic KS lesions (5/17).
- HPV-16 DNA was detected in KS cell cultures derived from both pleural effusion and skin lesions.
Conclusions:
- HPV-16-related DNA sequences are associated with diverse clinical presentations of Kaposi's sarcoma.
- These findings suggest a potential role for HPV-16 in the pathogenesis of KS.
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