Calculations for pH during CO2 and O2 exchange with blood

New mathematical formulas are presented to calculate directly the change in blood pH during CO2, and O2 exchange with blood. pH changes are calculated from changes in blood PCO2 and saturation values or from changes in blood PCO2 and blood PO2 values. Computational results agree well with information obtained from a Dill nomogram. These new formulas have applicability to the modelling of gas exchange in blood oxygenators as well as to estimating blood acid-base parameters following the mixing of blood samples.