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Updated: Sep 5, 2026
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Differential effects of CD4+ and CD8+ cells in acute, systemic murine candidosis
L A Coker1, C M Mercadal, B T Rouse
1Department of Microbiology, College of Liberal Arts, University of Tennessee, Knoxville 37996-0845.
Abstract:
Monoclonal antibody (mAb) depletion was used to assess contributions of CD4+ and CD8+ cells in resistance to systemic murine Candida albicans infection. Depletion of CD8+ cells did not influence either survival or mean survival time (MST); however, depletion of CD4+ cells significantly enhanced both survival and MST. Combined depletion of both CD4+ and CD8+ cells significantly lengthened the MST but did not enhance survival. A protective influence of CD8+ cells could be deduced but, to be manifested, required depletion of an overshadowing immunopathologic CD4+ response.
