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Related Experiment Videos

Proctolin activates an inward current whose voltage dependence is modified by extracellular Ca2+.

J Golowasch1, E Marder

  • 1Biology Department, Brandeis University, Waltham, Massachusetts 02254.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|March 1, 1992
PubMed
Summary

The neuropeptide proctolin excites crustacean neurons by depolarizing them near action potential threshold. This action, mediated by a sodium-dependent inward current, modulates neural network activity.

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Area of Science:

  • Neuroscience
  • Neurophysiology
  • Crustacean neurobiology

Background:

  • The pentapeptide proctolin is known to modulate neural circuits.
  • Proctolin excites specific neurons in the crustacean stomatogastric nervous system, leading to high-frequency action potential bursts.

Purpose of the Study:

  • To investigate the ionic mechanisms underlying proctolin's excitatory effects on stomatogastric ganglion neurons.
  • To characterize the electrical properties of the current evoked by proctolin.

Main Methods:

  • Electrophysiological recordings, including voltage clamp, were used to study proctolin's effects on neurons.
  • Experiments involved manipulating extracellular ion concentrations, specifically calcium (Ca2+).

Main Results:

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  • Proctolin depolarizes neurons maximally near the action potential generation threshold.
  • Proctolin evokes an inward current, partially carried by sodium (Na+), exhibiting strong outward rectification.
  • Removal of extracellular Ca2+ potentiates the proctolin-evoked current and linearizes its current-voltage relationship.

Conclusions:

  • The proctolin-evoked current's properties are well-suited for activity-dependent modulation of neural networks.
  • Proctolin's effects on neuronal excitability contribute to the dynamic control of rhythmic pattern generation in the stomatogastric nervous system.