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Antiviral agents.

M R Keating1

  • 1Division of Infectious Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905.

Mayo Clinic Proceedings
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Antiviral drugs inhibit viral replication but cannot target latent viruses. Increased use of these therapies leads to more frequent encounters with antiviral resistance.

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Area of Science:

  • Virology
  • Pharmacology

Background:

  • The development of antiviral therapies has significantly expanded, offering treatments for various viral infections.
  • Current antiviral agents primarily function by inhibiting specific stages of viral replication, acting as virustatic agents.

Framework:

  • Acyclovir is effective for herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections, including prophylaxis in immunocompromised individuals.
  • Ganciclovir is indicated for cytomegalovirus (CMV) retinitis in acquired immunodeficiency syndrome (AIDS) patients and other CMV infections in immunocompromised individuals.
  • Interferon alfa-2b shows efficacy in treating chronic hepatitis C and human papillomavirus (HPV)-induced condyloma acuminatum.
  • Zidovudine is recommended for human immunodeficiency virus (HIV) infection with CD4 counts below 500 cells/mm³.
  • Amantadine serves therapeutic and prophylactic roles in managing influenza A virus infections.

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Implementation:

  • Antiviral agents target specific viral replication steps, offering treatment for active infections.
  • Prophylactic use of antivirals is employed in immunocompromised patients to prevent herpesvirus infections.

Implications:

  • The expanding applications of antiviral therapies are increasingly associated with the emergence of clinically significant antiviral resistance.
  • Understanding resistance patterns is crucial for optimizing treatment strategies and managing viral infections effectively.