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Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 30, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Gene therapy for cancer.

A A Gutierrez¹, N R Lemoine, K Sikora

¹Department of Clinical Oncology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Lancet (London, England)

|March 21, 1992

Summary

This summary is machine-generated.

Gene transfer offers novel cancer therapies by targeting oncogenes and tumor suppressor genes. Techniques like antisense nucleic acids, ribozymes, and gene replacement hold promise for suppressing cancer and enhancing immune response.

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Area of Science:

Oncology
Molecular Biology
Gene Therapy

Background:

Cancer involves oncogene activation and tumor suppressor gene inactivation.
Genetic events in cancer present novel therapeutic targets.
Gene transfer offers potential strategies to modify somatic cells for cancer treatment.

Purpose of the Study:

To review the potential applications and ethical considerations of gene transfer in cancer therapy.
To explore how gene transfer can modulate gene expression and cellular behavior in cancer patients.

Main Methods:

Review of current gene transfer technologies and their applications in oncology.
Discussion of informational drugs (antisense nucleic acids, ribozymes) for gene expression modulation.
Exploration of genetic immunomodulation and targeted prodrug activation strategies.

Main Results:

Gene transfer can suppress malignant behavior by modulating oncogene and tumor suppressor gene expression.
Genetic immunomodulation can enhance anti-tumor immune responses.
Targeted gene transfer can improve chemotherapy efficacy and protect normal tissues.

Conclusions:

Gene transfer represents a promising frontier in cancer therapy, targeting key genetic alterations.
Ethical implications of somatic cell gene transfer require careful consideration.
Future directions include gene replacement therapy for restoring tumor suppressor function.