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The van Slyke equation.

O Siggaard-Andersen

    Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    The Van Slyke equation, alongside the Henderson-Hasselbalch equation, aids in calculating blood acid-base status. This provides an algorithm for determining key variables using pH, pCO2, and hemoglobin measurements.

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    Area of Science:

    • Physiology
    • Biochemistry

    Background:

    • The Henderson-Hasselbalch equation is crucial for understanding blood acid-base balance.
    • A similar equation is needed for the CO2 equilibration curve in blood.

    Purpose of the Study:

    • To introduce and define the Van Slyke equation for CO2 equilibration in blood.
    • To present a comprehensive algorithm for acid-base variable calculation.

    Main Methods:

    • The study proposes the Van Slyke equation: a - 24.4 = - (2.3 X b + 7.7) X (c - 7.40) + d/(1 - 0.023 X b).
    • Variables include bicarbonate, hemoglobin, plasma pH, and base excess.
    • The equation facilitates calculation using measured pH, pCO2, and hemoglobin.

    Main Results:

    • The Van Slyke equation quantifies the CO2 equilibration curve in vitro.

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  • Combined with the Henderson-Hasselbalch equation, it forms an arithmetic algorithm.
  • This algorithm allows for the calculation of various blood acid-base variables.

    • Conclusions:

    • The Van Slyke equation is proposed as a key tool for acid-base status assessment.
    • The two equations provide a practical method for calculating blood acid-base variables.
    • Accurate determination of acid-base status is essential in clinical settings.