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Updated: Jan 30, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Prenatal development of monoamine neurons in the rat]
Abstract:
The histofluorescence method allows the study of the prenatal development of monoamines neurons in the foetal rat brain. Certain patterns of this development can be defined: the locus niger and the raphe appears fluorescent on the 14th day, the locus coeruleus on the 15th day. These systems differentiate independently in various areas of the neural axis. Their maturation are progressive: first for the DA system, then for the NA and the 5 HT systems. The mechanisms for synthesis and storage of amines precede the complete development of the effector structures.
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