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Related Experiment Videos

Physiological viewpoints on clinical acid-base diagnostics.

K Engel, P Kildeberg

    Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
    |January 1, 1977
    PubMed
    Summary
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    This study redefines non-carbonic acid in body fluids, distinguishing between metabolizable (MA) and non-metabolizable (NA) components. This improved specificity aids in understanding organ-level acid-base physiology and diagnostics.

    Area of Science:

    • Physiology
    • Biochemistry

    Background:

    • Acid-base physiology traditionally examines hydrogen ion sources and control.
    • Carbon dioxide measurements improved understanding of pulmonary elimination.
    • Non-carbonic acid contributions present methodological challenges, with 'base excess' relevance debated.

    Purpose of the Study:

    • To improve specificity in acid-base physiology by subdividing non-carbonic acid.
    • To develop a more relevant physiological approach at the organ level.
    • To differentiate between metabolizable and non-metabolizable non-carbonic acid components.

    Main Methods:

    • Utilized micro-equilibration techniques for assessing non-volatile titratable acid in blood.
    • Proposed a novel subdivision of titratable non-carbonic acid into two components.

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  • Quantified metabolizable non-carbonic acid (MA) and non-metabolizable non-carbonic acid (NA).

    • Main Results:

    • Distinguishing MA and NA enhances specificity for organ-level acid-base physiology.
    • MA represents hydrogen ion donation reversible by metabolic means.
    • NA relates to transport, storage, and control of non-metabolizable acids in the GI tract, skeleton, and kidneys.

    Conclusions:

    • The proposed subdivision of non-carbonic acid offers improved specificity for physiological studies.
    • This distinction has implications for understanding acid-base balance in specific organs.
    • The findings support a more refined approach to acid-base diagnostics.