Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A magnetically actuated left ventricular assist device.

S G Kovacs1, D G Reynolds, P P McKeown

  • 1Department of Surgery, College of Medicine, University of Florida, Tampa.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generation and Characterization of Intense Ultralow-Emittance Electron Beams for Compact X-Ray Free-Electron Lasers.

Physical review letters·2019
Same author

Educational interventions in neurology: a comprehensive systematic review--reply to letter.

European journal of neurology·2013
Same author

Exercise training improves activity in adolescents with congenital heart disease.

Heart (British Cardiac Society)·2013
Same author

Educational interventions in neurology: a comprehensive systematic review.

European journal of neurology·2013
Same author

Laboratory studies of the microsporidian Plistophora culicis (Weiser) infecting Culex pipiens fatigans Wied.

Bulletin of entomological research·2012
Same author

Nutritional intake and oxidative stress in chronic heart failure.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2010
Same journal

Machine Learning Prediction of Pediatric In-Hospital Survival Before Extracorporeal Membrane Oxygenation Cannulation.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Erratum: Safety and Efficacy of Stored Wet-Preprimed Extracorporeal Membrane Oxygenation Circuits: A Scoping Review.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Case Series of Extracorporeal Cardiopulmonary Resuscitation for Refractory Cardiopulmonary Arrest After Cardiac Surgery.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Association Between Veno-Venous Extracorporeal Membrane Oxygenation and Right Ventricular Dysfunction in Acute Respiratory Distress Syndrome Patients: A Multicenter Retrospective Propensity-Matched Study.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Prolonged Mechanical Circulatory Support of Neonatal Biventricular Failure via Single Ventricle Conversion With Ventricular Assist Device.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Redefining Limits: Extracorporeal Cardiopulmonary Resuscitation in Adult Thrombotic Thrombocytopenic Purpura.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
See all related articles

A novel magnetic-actuated left ventricular assist device (LVAD) shows promise in maintaining hemodynamic stability during acute heart failure in sheep models. This innovative design simplifies components, enhancing reliability for potential clinical use.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Device Development

Background:

  • Traditional ventricular assist devices (VADs) often involve complex mechanical components.
  • Complexity in VADs can lead to reduced reliability and increased failure rates.
  • A simplified, reliable VAD design is crucial for improving patient outcomes.

Purpose of the Study:

  • To develop and evaluate a novel, small, lightweight, and power-efficient left ventricular assist device (LVAD) utilizing magnetic actuation.
  • To assess the hemodynamic performance of this new LVAD in an acute animal model of ventricular dysfunction.
  • To demonstrate the feasibility and potential benefits of magnetic actuation in VAD technology.

Main Methods:

  • Design and fabrication of a magnetic-actuated LVAD with specific weight, size, and power parameters.

Related Experiment Videos

  • In vitro testing using a mock loop to refine pump and actuator design.
  • In vivo assessment in four sheep experiencing induced acute ventricular dysfunction (beta blockade, coronary ligation, ventricular fibrillation).
  • Monitoring of hemodynamic parameters including mean aortic pressure and pump flow rate.

    • Main Results:

    • The magnetic-actuated LVAD demonstrated the ability to increase mean aortic pressure by 45-50 mmHg during induced heart failure conditions.
    • Pump flow rates ranged from 2.71 L/min to 4.6 L/min at a pump rate of 100 beats per minute.
    • While two sheep survived the 6-hour test period, global fibrillation was identified as a primary cause of failure in others, indicating areas for future improvement.

    Conclusions:

    • The developed magnetic-actuated LVAD shows significant potential for maintaining critical hemodynamic parameters under acute left ventricular dysfunction.
    • The simplified design, driven by magnetic actuation, offers improved reliability compared to traditional VADs.
    • Further research and testing, including in calf models, are warranted to optimize performance and explore long-term viability.