Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Primary hypothyroidism in normal thyroid gland morphology].

S C Heik1, M Wolf, H Greten

  • 1Medizinische Kernklinik und Poliklinik, Univ.-Krankenhaus Eppendorf, Hamburg.

Fortschritte Der Medizin
|February 28, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Met326Ile aminoacid polymorphism in the human p85 alpha gene has no major impact on early insulin signaling in type 2 diabetes.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2004
Same author

A new model of primary human adipocytes reveals reduced early insulin signalling in type 2 diabetes.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2004
Same author

Principles of prevention of cardiovascular disease.

European heart journal·2004
Same author

[Primary prevention of cardiovascular diseases. Stepchild of internal medicine].

Der Internist·2004
Same author

Severe myelitis following infection with Campylobacter enteritis.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2004
Same author

[Pravastatin for older patients with risk of vascular disease. The PROSPER-Study].

Der Internist·2003

A young patient developed hypothyroidism due to thyrotropin inhibiting immunoglobulins. This autoimmune condition targets thyroid function without destroying thyroid tissue, as indicated by specific antibody presence and normal gland histology.

Area of Science:

  • Endocrinology
  • Immunology
  • Pathology

Background:

  • Autoimmune hypothyroidism can arise from various mechanisms.
  • Thyroid-specific antibodies play a crucial role in diagnosing and understanding thyroid dysfunction.
  • Understanding the specific pathogenic pathways is key for effective management.

Observation:

  • A 25-year-old patient presented with hypothyroidism and antibodies against thyroglobulin, thyroid microsomes, and thyrotropin receptors.
  • Thyroid imaging showed 0% 99m-technetium uptake, indicating minimal to no thyroid hormone synthesis.
  • Ultrasound revealed a normal-sized, homogenous thyroid gland, while histology showed lymphocyte infiltration with regular follicles.

Findings:

  • The presence of antibodies against thyrotropin receptors suggests an autoimmune attack on the thyroid-stimulating hormone (TSH) signaling pathway.

Related Experiment Videos

  • Histological findings of lymphocyte infiltration without parenchymal destruction point towards a functional impairment rather than tissue loss.
  • The combination of clinical presentation, antibody profile, and histological findings supports the diagnosis of hypothyroidism mediated by thyrotropin inhibiting immunoglobulins.

    • Implications:

    • This case highlights a specific autoimmune mechanism of hypothyroidism not characterized by thyroid tissue destruction.
    • Identifying thyrotropin inhibiting immunoglobulins as the cause offers insights into non-destructive autoimmune thyroid disease.
    • Further research into such immunoglobulins could lead to targeted therapies for specific autoimmune thyroid conditions.