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Genetic evidence that placental site trophoblastic tumours can originate from a hydatidiform mole or a normal
R A Fisher1, F J Paradinas, E S Newlands
1Cancer Research Campaign Laboratories, Charing Cross and Westminster Medical School, London, UK.
British Journal of Cancer
|March 1, 1992
Abstract:
The genetic origin of two placental site trophoblastic tumours was established using a Y chromosome-specific and locus-specific minisatellite probes. A gestational origin was confirmed for both tumours. In one case the origin of the tumour was consistent with derivation from a normal female conceptus while the other was shown to arise from a homozygous complete hydatidiform mole, an abnormal conceptus more usually associated with the development of choriocarcinoma.