Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Embryonal germ-layer antigens: target for autoimmunity.

B Tadmor1, C Putterman, Y Naparstek

  • 1Clinical Immunology and Allergy Unit, Hadassah University Hospital, Ein-Kerem, Jerusalem, Israel.

Lancet (London, England)
|April 18, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-IFNAR treatment does not reverse neuropsychiatric disease in MRL/<i>lpr</i> lupus mice.

Lupus·2019
Same author

A Markov Multi-State model of lupus nephritis urine biomarker panel dynamics in children: Predicting changes in disease activity.

Clinical immunology (Orlando, Fla.)·2018
Same author

The blood-brain barrier, TWEAK, and neuropsychiatric involvement in human systemic lupus erythematosus and primary Sjögren's syndrome.

Lupus·2018
Same author

Educational interventions encouraging appropriate use of blood transfusions.

Vox sanguinis·2017
Same author

Urinary high-mobility group box-1 associates specifically with lupus nephritis class V.

Lupus·2016
Same author

A liposomal steroid nano-drug for treating systemic lupus erythematosus.

Lupus·2016
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
Same journal

Dual mobility total hip replacement in fractures: stability promotes patient confidence.

Lancet (London, England)·2026
Same journal

Dual mobility versus standard cups in total hip replacement for displaced femoral neck fractures (Duality): an international, multicentre, randomised, controlled, superiority trial.

Lancet (London, England)·2026
See all related articles

Systemic autoimmune diseases may target organs based on their shared embryonic origin. Researchers propose that common germ layer antigens could be the targets of autoimmune responses.

Area of Science:

  • Immunology
  • Developmental Biology
  • Pathology

Background:

  • Systemic autoimmune diseases involve multiple organs.
  • Histopathological analysis reveals commonalities in affected organs.

Purpose of the Study:

  • To investigate the potential link between organ embryonal origin and autoimmune disease involvement.
  • To propose a hypothesis for autoimmune response targeting based on germ layer origin.

Main Methods:

  • Histopathological analysis of organs affected by systemic autoimmune diseases and syndromes.
  • Comparative analysis of organ origins based on embryological germ layers.

Main Results:

  • A common feature identified in affected organs is their shared embryonal origin.

Related Experiment Videos

  • Organs originating from the same germ layer may express common, specific antigens.

    • Conclusions:

    • The shared embryonal origin of organs is a potential unifying factor in systemic autoimmune diseases.
    • Germ layer-specific antigens are proposed as potential targets for autoimmune responses, explaining multi-organ involvement.