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[Pharmaco-angiography with Priscolin in progressive scleroderma (author's transl)].
Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|September 1, 1976
Summary
Progressive scleroderma causes obliterative changes in digital arteries, even in early stages. Vasodilators like Priscolin can influence digital artery hemodynamics, but irreversible contrast stasis may persist.
Area of Science:
- Vascular Medicine
- Rheumatology
- Dermatology
Background:
- Scleroderma is a progressive autoimmune disease characterized by fibrosis and vascular abnormalities.
- Digital artery involvement is a common and debilitating manifestation of scleroderma.
Purpose of the Study:
- To describe the morphological and hemodynamic changes in forearm and hand vessels in patients with progressive scleroderma.
- To evaluate the effect of intra-arterial Priscolin on digital artery hemodynamics.
Main Methods:
- Brachial arteriography was performed on 21 patients with progressive scleroderma before fibrinolytic therapy.
- Arteriograms were obtained before and after intra-arterial Priscolin administration.
- Morphological and hemodynamic findings were compared across different stages of the disease.
Main Results:
- Obliterative changes in digital arteries are present even in the early edematous stage of scleroderma.
- Vascular changes progress in severity between the edematous and advanced stages.
- Priscolin influenced digital artery hemodynamics, offering insights into the arterial microcirculation.
- Irreversible contrast stasis was observed during the edematous stage, unaffected by Priscolin.
Conclusions:
- Digital artery pathology in scleroderma begins early and progresses with disease severity.
- Intra-arterial Priscolin can modulate digital artery hemodynamics, suggesting potential therapeutic avenues.
- The presence of irreversible contrast stasis indicates significant microcirculatory compromise unresponsive to vasodilators.