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A dementing illness associated with a novel insertion in the prion protein gene
F Owen1, M Poulter, J Collinge
1Department of Physiological Sciences, University of Manchester, U.K.
Brain Research. Molecular Brain Research
|March 1, 1992
Abstract:
Following our previous report of an 144-bp insertion in the open reading frame of the prion protein (PrP) gene, we have now identified a larger, 216-bp, insertion in the gene. The insertion which is in frame encodes 9 extra octapeptide repeat sequences in addition to the 5 repeats normally present and represents the largest insertion so far detected in the PrP gene.