[The mechanism of action of benzodiazepine and its consequences for therapy]

Kinetics and mechanism of action of benzodiazepines are at the base of their proper use in clinical management of anxiety, tension, panics, and insomnia. These important agents have specific receptors within the complex GABA-ergic system: according to the most recent studies, GABAA receptors are more important than GABAB receptors. The author illustrates the management of anxiety states, as well as the treatment of anxiety in children, in old people and of panic attacks. Since the use of benzodiazepines has become excessive, the risk of dependence is discussed as well as possible alternatives (buspirone, antidepressants). Finally, the usefulness of anxiolytic drug treatment is stressed which is one of the pivots of psychopharmacology and the study of the GABA-ergic system.