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Updated: Aug 9, 2026
08:09
CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
Published on: August 4, 2016
Human intercellular adhesion molecule-1 gene and its expression in the skin
S W Caughman1, L J Li, K Degitz
1Department of Dermatology, Veteran Affairs Medical Center, Atlanta, Georgia.
The Journal of Investigative Dermatology
|June 1, 1992
Summary
Intercellular adhesion molecule-1 (ICAM-1) plays a key role in skin inflammation by mediating leukocyte interactions. Researchers identified regulatory elements in the ICAM-1 gene
Area of Science:
- Immunology
- Dermatology
- Molecular Biology
Background:
- Cell adhesion molecules (CAMs) are crucial for cell-cell interactions, particularly in immune responses.
- Differential expression of CAMs is implicated in skin inflammation, immune responses, and wound repair.
- Intercellular adhesion molecule-1 (ICAM-1) is expressed on endothelial cells and keratinocytes, regulating leukocyte adhesion in the skin.
Purpose of the Study:
- To investigate the molecular mechanisms regulating Intercellular adhesion molecule-1 (ICAM-1) gene transcription in cutaneous inflammation.
- To identify and characterize regulatory elements within the 5' flanking region of the ICAM-1 gene.
Main Methods:
- Isolation and characterization of human genomic clones containing the 5' regulatory region of the ICAM-1 gene.
- Analysis of consensus regulatory elements within the identified 5' flanking region.
Main Results:
- Genomic clones of the ICAM-1 5' regulatory region were successfully isolated and characterized.
- Consensus regulatory elements potentially involved in ICAM-1 gene transcription were identified in the 5' flanking region.
Conclusions:
- ICAM-1 gene expression is regulated at the transcriptional level.
- The identified regulatory elements are crucial for understanding ICAM-1's role in cutaneous inflammation and developing anti-inflammatory strategies.
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