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[Acral vasospasm in Crohn's disease].

P Gasser1, H Affolter, J P Schuppisser

  • 1Internmedizinische und chirurgische Abteilung, St. Claraspital Basel.

Schweizerische Medizinische Wochenschrift
|May 2, 1992
PubMed
Summary

Patients with Crohn's disease exhibit impaired microcirculation, showing prolonged blood flow cessation during cold exposure and reduced capillary density. This suggests a vasospastic tendency in Crohn's disease affecting finger microcirculation.

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Area of Science:

  • Gastroenterology
  • Microcirculation Research
  • Vasospasm Studies

Context:

  • Crohn's disease is a chronic inflammatory bowel condition.
  • Microcirculatory abnormalities are increasingly recognized in systemic diseases.
  • Nailfold capillaroscopy is a non-invasive method to assess microcirculation.

Purpose:

  • To investigate microcirculatory abnormalities in patients with Crohn's disease.
  • To assess digital capillary blood flow and vasoconstrictive responses.
  • To compare nailfold capillary microscopy findings between Crohn's disease patients and healthy controls.

Summary:

  • Fifty-five Crohn's disease patients and 55 controls underwent nailfold capillary microscopy.
  • Patients showed significantly reduced capillary density (p < 0.001) and prolonged blood flow cessation upon cold exposure (mean 39s vs 19s).
  • No significant difference in skin temperature was observed between groups, indicating a vasospastic tendency.

Impact:

  • Findings suggest a vasospastic tendency in the microcirculation of Crohn's disease patients.
  • Highlights potential diagnostic utility of nailfold capillaroscopy in assessing disease-related microvascular changes.
  • Opens avenues for further research into the role of microvascular dysfunction in Crohn's disease pathogenesis.

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