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Impairment of some granulocyte functions in Sweet's syndrome
P von den Driesch1, M Simon, R Schlegel Gomez
1Department of Dermatology, University of Erlangen-Nürnberg, Germany.
Acta Dermato-Venereologica
|January 11, 1992
Abstract:
Chemotaxis, phagocytic and intracellular killing activities of polymorphonuclear leukocytes (PMNL) were investigated in vitro in 7 patients suffering from the acute phase of Sweet's syndrome. A moderate but consistent impairment of neutrophilic chemotactic activity (NCA) was revealed in all patients. Intracellular killing of blastospores of Candida albicans was diminished in 5/7 patients. Phagocytosis and oxidase activities were within normal levels. These results point to an alteration of some PMNL functions in the acute phase of Sweet's syndrome.