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Mucosal desquamation in psoriasis.

B Kumar1, I Kaur, G P Thami

  • 1Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Acta Dermato-Venereologica
|January 1, 1992
PubMed
Summary
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Urinary epithelial cell counts are elevated in patients with active plaque psoriasis. These cell counts decreased significantly following psoriasis treatment, indicating a link between skin condition and urinary cells.

Area of Science:

  • Urology
  • Dermatology
  • Cell Biology

Background:

  • Plaque psoriasis is a chronic inflammatory skin condition.
  • Urinary epithelial cells (UECs) are shed from the urinary tract lining.
  • The relationship between psoriasis and UECs is not well-established.

Purpose of the Study:

  • To investigate urinary epithelial cell counts in patients with active plaque psoriasis.
  • To compare UEC counts between psoriatic patients and healthy controls.
  • To assess changes in UEC counts following psoriasis treatment.

Main Methods:

  • Urinary samples were collected from 102 patients with active plaque psoriasis and a control group.
  • Urinary epithelial cell counts were quantified.
  • Cell counts were analyzed before and after therapeutic regression of psoriatic lesions.

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Main Results:

  • Patients with active plaque psoriasis exhibited significantly higher UEC counts compared to controls.
  • A statistically significant reduction in UEC counts was observed after successful treatment and regression of psoriasis.
  • UEC levels correlated with disease activity.

Conclusions:

  • Elevated urinary epithelial cell counts are associated with active plaque psoriasis.
  • Monitoring UEC counts may offer insights into psoriasis activity and treatment response.
  • Further research is warranted to elucidate the mechanisms linking psoriasis and urinary tract changes.