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Suction blister fluid histamine in fixed drug eruption
1Department of Dermatology, Helsinki University Central Hospital, Finland.
Acta Dermato-Venereologica
|January 1, 1992
Summary
Histamine release occurs early in fixed drug eruptions (FDE) after drug challenge. This study shows elevated histamine in FDE lesions, suggesting it mediates symptoms.
Area of Science:
- Dermatology
- Pharmacology
- Immunology
Background:
- Fixed drug eruption (FDE) is a cutaneous reaction to specific medications.
- The precise mediators involved in FDE pathogenesis are not fully elucidated.
Purpose of the Study:
- To investigate the role of histamine in the early stages of fixed drug eruption.
- To quantify histamine levels in lesional and uninvolved skin during FDE.
Main Methods:
- Histamine concentrations were measured in suction blister fluid from FDE patients and healthy controls.
- Samples were collected before and at multiple time points after oral challenge with phenazone salicylate.
Main Results:
- Histamine levels were significantly elevated in FDE lesions shortly after drug challenge.
- Elevated histamine was observed in both lesional and uninvolved skin at later time points.
- Histamine levels in lesional skin were significantly higher than in control skin.
Conclusions:
- Direct evidence supports early histamine release from mast cells or basophils in FDE.
- Histamine is implicated as a key mediator of the clinical symptoms in fixed drug eruptions.