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Elevated IgG anti-histone antibodies in a subgroup of medicated schizophrenic patients
K N Chengappa1, A B Carpenter, Z W Yang
1Department of Psychiatry, Western Psychiatric Institute & Clinic, Pittsburgh, PA 15213-2593.
Schizophrenia Research
|April 1, 1992
Abstract:
A total of 57 schizophrenic patients (of which 17 were first-episode, neuroleptic naive) and 76 healthy controls were screened for anti-histone IgG antibodies using an enzyme immunoassay (ELISA). All patients had significantly higher anti-histone antibody titers than controls (t = 3.1, p less than 0.003). Previously medicated patients had significantly higher titers than neuroleptic-naive first episode patients (t = 2.87, p less than 0.006). This study suggests that neuroleptic medications are associated with anti-histone antibodies.