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[Prevention of migraine using bisoprolol. Results of a double-blind study versus metoprolol]
R Wörz1, B Reinhardt-Benmalek, M Föh
1Schmerzzentrum Bad Schönborn.
Aims:
Comparison of bisoprolol, a beta-1 selective beta blocker with no intrinsic sympathomimetic activity (ISA) and metoprolol, which numerous studies have shown to be an effective migraine prophylactic.
Study Design:
Multicentric, cross-over study.
Patients:
125 patients suffering at least from 3 attacks of classic or common migraine a month for at least two years.
Treatment:
Bisoprolol 5 mg given once a day, or metoprolol 50 mg given twice a day, for two periods of 12 weeks.
Results:
125 patients were admitted to the 4-week run-in phase. A comparison of the main target: frequency of migraine attacks was thus carried out in 78 patients (f. = 63, m. = 15). Both substances reduced the average frequency of migraine per 28-day period by about 50%. There was no statistically significant difference between the two beta-blockers (p greater than 0.05).
Conclusions:
The results of the study show that 5 mg of bisoprolol and 100 mg of metoprolol a day have comparable efficacy for migraine prophylaxis, and show comparable tolerability.