[Thrombocyte aggregation in depression and activation of the anticoagulation system of blood in animals]

It was demonstrated in rat experiments that function inhibition of the anticoagulation system by means of intravenous injections of high doses of antiplasmin and aminasine resulted not only in certain changes in the blood coagulation parameters, but also in increased platelets aggregation. The appearance of increased quantities of free thrombin in the circulating blood may be one of the mechanisms favouring increased aggregation of platelets. The activation of the function of the anticoagulation system induced in experimental animals by intravenous injections of low doses of adrenalin, antiplasmin (12 U/200 g of body weight) and tissue thromboplastin results, along with hypocoagulation and enhanced enzymatic and non-enzymatic fibrinolysis, in a decreased platelets aggregation.