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Related Experiment Videos

Beta-adrenergic agonists for acute, severe asthma.

H W Kelly1, S Murphy

  • 1College of Pharmacy, University of New Mexico, Albuquerque 87131.

The Annals of Pharmacotherapy
|January 1, 1992
PubMed
Summary

Beta-adrenergic agonists are the preferred bronchodilators for acute, severe asthma, especially when administered via aerosol. Intravenous beta-agonists are not recommended due to safety concerns.

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Area of Science:

  • Pulmonology
  • Pharmacology

Background:

  • Acute, severe asthma requires effective bronchodilator therapy.
  • Beta-adrenergic agonists are commonly used for asthma management.

Purpose of the Study:

  • To critically review the use of beta-adrenergic agonists in acute, severe asthma.
  • To focus on aerosol administration of these agents.

Main Methods:

  • Systematic review of English language articles published since 1971.
  • Included studies comparing systemic versus inhaled beta-agonists.
  • Analyzed studies on aerosol delivery and intravenous beta-agonists.

Main Results:

  • Aerosolized beta-agonists are more effective and safer than methylxanthines and anticholinergics.
  • Inhaled beta-agonists are as effective or more effective than parenteral administration with fewer cardiovascular side effects.
  • Nebulization is favored over metered-dose inhalers for ease of administration.

Conclusions:

  • Aerosolized selective beta 2-agonists are the optimal bronchodilator choice for acute, severe asthma.
  • Optimal dosing and delivery are crucial for effective treatment.
  • Intravenous beta-agonists are hazardous and should be avoided.

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