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Related Experiment Videos

T lymphocyte changes in open heart surgery.

G J Wu1, H Chang, M J Wang

  • 1Department of Anesthesiology, National Taiwan University Hospital, Taipei, R.O.C.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|January 1, 1992
PubMed
Summary
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Open heart surgery temporarily reduces T lymphocytes and their subsets after cardiopulmonary bypass. These immune cell levels returned to normal by the second postoperative day, with no observed infections.

Area of Science:

  • Immunology
  • Cardiovascular Surgery

Background:

  • Open heart surgery involves cardiopulmonary bypass (CPB), potentially impacting immune function.
  • T lymphocytes are crucial for cellular immunity and can be affected by surgical stress.

Purpose of the Study:

  • To investigate the transient effects of open heart surgery on T lymphocyte populations and their subsets.
  • To assess the recovery of T lymphocyte subsets after cardiopulmonary bypass.

Main Methods:

  • Flow cytometry and monoclonal antibodies were used to analyze T lymphocyte subsets (T3, T4, T8) in 20 patients.
  • Blood samples were collected pre-operatively, during surgery, and on postoperative days 1 and 2.

Main Results:

  • T lymphocyte percentages (total, helper, suppressor) significantly decreased on postoperative day 1 compared to pre-operative levels.

Related Experiment Videos

  • Immune cell counts returned to baseline by postoperative day 2.
  • The ratio of helper to suppressor T cells remained stable throughout the study.

    • Conclusions:

    • Open heart surgery causes a transient, significant decrease in T lymphocytes and their subsets.
    • Immune function recovers within two days post-surgery, without apparent clinical consequences like infection.