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Updated: Aug 12, 2026

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Published on: April 1, 2019
T cell receptor gamma variable gene locus polymorphism in patients with rheumatoid arthritis
I Chaouni1, M P Lefranc, A D d'Angeac
1INSERM U291, Montpellier, France.
Objective:
We sought new susceptibility markers for rheumatoid arthritis (RA) among the T cell receptor gamma (TCR gamma) genes.
Methods:
We analyzed restriction fragment length polymorphisms (RFLP) of the first variable subgroup of TCR gamma genes in a group of French control subjects and a group of French RA patients.
Results:
No significant difference in Eco RI RFLP was found between the 2 study populations: Allele frequencies were virtually identical. There was no polymorphism using Hind III.
Conclusion:
These results exclude TCRV gamma I polymorphism as a disease susceptibility marker in RA.
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