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The effect of anti-adhesion molecule antibody on the development of collagen-induced arthritis
K Kakimoto1, T Nakamura, K Ishii
1Department of Biochemistry, Kumamoto University Medical School, Japan.
Cellular Immunology
|July 1, 1992
Abstract:
In order to study how inflammatory cells including autoimmune lymphocytes interact with each other to develop collagen-induced arthritis (CIA), we injected monoclonal antibodies against mouse LFA-1 and ICAM-1 into DBA/1 mice immunized with type II collagen (CII). Both antibodies suppressed the development of CIA. These antibodies showed no effect on anti-CII antibody response, although they both significantly suppressed DTH response. It was suggested that anti-adhesion molecule antibodies suppress CIA mainly through their effect on cell-mediated immunity, without affecting humoral immunity under the conditions used.