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Related Concept Videos

Blood Pressure01:30

Blood Pressure

Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the diastolic...
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...

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Related Experiment Video

Updated: Jun 29, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

Primary aldosteronism: hypertension with a genetic basis.

R D Gordon1, S A Klemm, T J Tunny

  • 1University Department of Medicine, Greenslopes Hospital, Brisbane, Queensland, Australia.

Lancet (London, England)
|July 18, 1992
PubMed
Summary

Primary aldosteronism is a spectrum of genetic diseases, with new subtypes identified. Biochemical screening reveals it

Area of Science:

  • Endocrinology
  • Genetics
  • Molecular Biology

Background:

  • Primary aldosteronism is increasingly recognized due to advances in biochemical screening.
  • Genetic discoveries have identified new subtypes and elucidated the molecular basis of existing ones.

Purpose of the Study:

  • To describe new subtypes of primary aldosteronism.
  • To elucidate the genetic basis of primary aldosteronism subtypes.
  • To propose a unified spectrum of primary aldosteronism based on genetic and morphological diversity.

Main Methods:

  • Biochemical screening (aldosterone/renin ratio) for early diagnosis.
  • Genetic analysis to identify mutations and gene functions.
  • Histopathological examination of adrenal tissue.

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Last Updated: Jun 29, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
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Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta
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Main Results:

  • Identified a glucocorticoid-suppressible variety (FHI) with a mutant gene affecting aldosterone synthesis regulation.
  • Described angiotensin II-responsive aldosterone-producing adenomas (AII-responsive APA) with distinct cellular composition and steroid production.
  • Characterized a new familial form (FHII) of primary aldosteronism involving tumors and lacking glucocorticoid suppressibility.
  • Demonstrated that primary aldosteronism subtypes exhibit varying responses to ACTH and angiotensin II.

Conclusions:

  • Primary aldosteronism encompasses a spectrum of genetic disorders manifesting as hyperplasia or neoplasia.
  • Morphological and genetic heterogeneity underlies the diverse biochemical and clinical presentations of primary aldosteronism.
  • Further research into genetic subtypes will refine diagnosis and management of primary aldosteronism.