Related Experiment Videos
Gamma glutamyl transpeptidase in meningitis
1Department of Medicine IV and Biochemistry, Medical College and Hospital, Rohtak.
The Journal of the Association of Physicians of India
|March 1, 1992
Summary
Cerebrospinal fluid (CSF) gamma glutamyl transpeptidase (GGTP) is elevated in meningitis. Serial increases in CSF GGTP indicate a poor prognosis and potential fatality in meningitis patients.
Area of Science:
- Neurology
- Clinical Chemistry
Background:
- Meningitis, an inflammation of the membranes surrounding the brain and spinal cord, presents diagnostic challenges.
- Gamma glutamyl transpeptidase (GGTP) is an enzyme with potential utility in various clinical conditions.
Purpose of the Study:
- To investigate the diagnostic and prognostic significance of gamma glutamyl transpeptidase (GGTP) in cerebrospinal fluid (CSF) and serum of meningitis patients.
- To differentiate between pyogenic and tuberculous meningitis using GGTP levels.
Main Methods:
- Serial measurement of GGTP activity in CSF and serum.
- Comparison of GGTP levels in 23 meningitis cases (15 pyogenic, 8 tuberculous) with age and sex-matched healthy controls.
Main Results:
- Significantly elevated GGTP levels in CSF and serum of meningitis patients compared to controls (p < 0.001).
- Higher GGTP levels observed in pyogenic meningitis versus tuberculous meningitis (p < 0.001) and in CSF compared to serum (p < 0.001).
- A serial rise in GGTP activity was associated with fatal outcomes in 8 cases.
Conclusions:
- CSF GGTP is a significant biomarker for meningitis diagnosis.
- Serial monitoring of CSF GGTP activity can predict poor prognosis and fatal outcomes in meningitis.