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Terazosin: a new alpha adrenoceptor blocking drug.
1Pharmaceutical Research and Development Division, Abbott Laboratories, Abbott Park, Illinois 60064.
Journal of Clinical Pharmacology
|June 1, 1992
Summary
Terazosin is a selective alpha 1-adrenoceptor blocker for hypertension. It offers a longer duration of action and improved water solubility compared to prazosin, enabling once-daily dosing.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
Background:
- Terazosin is a selective alpha 1-adrenoceptor antagonist.
- It is used for treating mild-to-moderate hypertension.
Purpose of the Study:
- To evaluate the efficacy and safety of terazosin.
- To compare its properties with prazosin.
Main Methods:
- Pharmacological characterization of terazosin.
- Clinical evaluation in hypertensive patients.
Main Results:
- Terazosin demonstrates a longer elimination half-life and greater water solubility than prazosin.
- It effectively lowers blood pressure and improves lipid profiles.
- Terazosin is safe and effective for long-term hypertension management, alone or with other agents.
Conclusions:
- Terazosin's pharmacokinetic advantages allow for once-daily administration.
- It is a valuable therapeutic option for essential hypertension.