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[Schizophrenia and Wilson's disease].

M Saint-Laurent1

  • 1Université de Montréal, Québec.

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

This case study highlights Wilson's disease misdiagnosed as schizophrenia. Early diagnosis and copper chelation are crucial for managing both neurological and psychiatric symptoms effectively.

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Area of Science:

  • Neurology
  • Psychiatry
  • Genetics

Background:

  • Wilson's disease is a rare genetic disorder.
  • It causes copper accumulation in organs, including the brain.
  • Neurological and psychiatric symptoms can mimic other conditions.

Observation:

  • An 18-year-old male initially presented with acute psychosis, later diagnosed as paranoid schizophrenia.
  • He experienced neurological symptoms, primarily parkinsonism, which worsened with antipsychotic medication.
  • Wilson's disease was diagnosed 12 years after his initial psychiatric hospitalization.

Findings:

  • Chelation therapy with d-penicillamine led to partial improvement in neurological symptoms.
  • Psychiatric symptoms also improved, requiring fewer antipsychotics.

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  • Delayed diagnosis limited the full efficacy of chelation treatment.

    • Implications:

    • This case underscores the importance of considering Wilson's disease in atypical psychiatric and neurological presentations.
    • Early diagnosis and intervention are critical for better patient outcomes.
    • Cerebral copper intoxication may be a significant factor in psychiatric manifestations.