Related Experiment Videos
A new chromosomal breakpoint in Ph positive, bcr negative chronic myelogenous leukemia. Report of a case
M Negrini1, A Tallarico, I Pazzi
1Interdepartment Center for Cancer Research, University of Ferrara, Italy.
Cancer Genetics and Cytogenetics
|July 1, 1992
Abstract:
We report a new case of Ph positive chronic myeloid leukemia (CML) without the classical rearrangement in Mbcr. By Southern blot analysis the molecular breakpoint was mapped 3 to 8 kb upstream of Mbcr. This region has not been shown to be rearranged in any other described case of CML. We did not detect any specific abnormal BCR-ABL transcript even with the use of the very sensitive RNA-PCR technique.