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[Effects of beta blocking agent iontophoresis by modulated sinusoidal current]
G R Ghighineishvili1, V Balsamo, P G Sirtori
1Centro Scientifico Pansovietico di Riabilitazione e Terapia Fisica, Università degli Studi di Milano.
La Clinica Terapeutica
|June 11, 1992
Summary
Transcutaneous propranolol via iontophoresis reduces heart rate without decreasing cardiac contractility. Only the active levogyral isomer of propranolol effectively penetrates the skin barrier.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Drug Delivery Systems
Background:
- Myocardial ischemia and infarction pose significant cardiovascular risks.
- Propranolol is a beta-blocker commonly used for cardiovascular conditions.
- Transdermal drug delivery offers an alternative administration route.
Purpose of the Study:
- To investigate the effects of transcutaneous propranolol administration via iontophoresis.
- To determine the impact of this delivery method on cardiac contractility and heart rate.
- To assess the skin permeability of propranolol isomers.
Main Methods:
- Utilized modulated sinusoidal current iontophoresis for transcutaneous propranolol delivery.
- Studied 58 male patients (32-62 years) post-aortocoronary bypass for myocardial ischemia.
- Included 34 patients with a history of myocardial infarction.
Main Results:
- Transcutaneous propranolol maintained negative chronotropic effects (reduced heart rate).
- The drug demonstrated an increase in cardiac contractility, unlike traditional administration.
- Confirmed that only the levogyral isomer of propranolol, the pharmacologically active form, permeates the skin.
Conclusions:
- Transcutaneous iontophoresis of propranolol offers a method to reduce heart rate while enhancing cardiac contractility.
- This delivery route selectively allows the active levogyral isomer of propranolol to cross the skin.
- Iontophoresis presents a potentially advantageous route for propranolol administration in cardiovascular patients.