Distribution of polymorphic HLA-DR and -DQ alleles as determined by restriction fragment length polymorphism analysis
G F Fischer1, I Faé, W F Pickl
1Institut für Blutgruppenserologie Universität Wien, Austria.
Abstract:
The restriction fragment length polymorphism (RFLP) of HLA-DR beta, -DQ alpha and -DQ beta genes was analyzed in 637 unrelated individuals from the Austrian population. The restriction enzyme was Taq I, and three exon-specific probes were applied. The gene frequencies, the Hardy-Weinberg equilibrium in DR beta and DQ loci, linkage disequilibria between the loci and haplotype frequencies are calculated. Rare associations between DR and DQ loci are described. Two RFLP patterns are demonstrated which were unique in the overall 1,000 individuals tested so far.
Related Concept Videos
Pedigree Analysis
Multiple Allele Traits
Hardy-Weinberg Principle
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...


