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Updated: Jun 23, 2026

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Sulphasalazine induced renal failure.

A D Dwarakanath1, J Michael, R N Allan

  • 1Department of Renal Medicine, Queen Elizabeth Hospital, Birmingham.

Gut
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Long-term sulphasalazine treatment for ulcerative colitis can lead to chronic kidney disease, specifically drug-induced chronic intestinal nephritis. This highlights the importance of monitoring renal function in patients on this medication.

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Area of Science:

  • Nephrology
  • Gastroenterology
  • Pharmacology

Background:

  • Ulcerative colitis is a chronic inflammatory bowel disease.
  • Sulphasalazine is a common medication used to manage ulcerative colitis.
  • Long-term use of medications can sometimes lead to adverse effects.

Observation:

  • Two male patients with a history of ulcerative colitis were treated with sulphasalazine for several years.
  • Both patients developed chronic renal failure.
  • Renal biopsy revealed histological changes indicative of drug-induced chronic intestinal nephritis.

Findings:

  • Extensive investigations ruled out other potential causes of chronic renal failure in these patients.
  • The findings suggest a causal link between sulphasalazine therapy and the development of chronic kidney disease.
  • One patient received a successful renal transplant, while the other maintained stable but impaired renal function.

Implications:

  • This case report underscores the potential nephrotoxic effects of long-term sulphasalazine use.
  • Regular monitoring of renal function is crucial for patients undergoing prolonged sulphasalazine treatment.
  • Further research may be warranted to elucidate the precise mechanisms of sulphasalazine-induced nephropathy.