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Calcium-dependent transmitter secretion reconstituted in Xenopus oocytes: requirement for synaptophysin

J Alder1, B Lu, F Valtorta

  • 1Department of Biological Sciences, Columbia University, New York, NY 10027.

Science (New York, N.Y.)
|July 31, 1992
PubMed

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Fusion of Secretory Vesicles with the Plasma Membrane01:26

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Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...