Related Experiment Videos
Sinusitis in HIV-1 infection.
J J Zurlo1, I M Feuerstein, R Lebovics
1National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
The American Journal of Medicine
|August 1, 1992
Summary
Sinusitis is common in patients with human immunodeficiency virus (HIV). This condition often presents without symptoms and may be linked to decreased immune function in HIV-infected individuals.
Area of Science:
- Infectious Diseases
- Immunology
- Radiology
Background:
- Sinusitis is a common condition.
- Patients with human immunodeficiency virus type 1 (HIV-1) infection may be at increased risk for various infections, including those affecting the sinuses.
Purpose of the Study:
- To characterize the clinical and radiographic features of sinusitis in patients with HIV-1 infection.
Main Methods:
- Retrospective study of 145 HIV-1 infected patients who underwent sinus imaging (radiographs, CT, or MRI) between 1982 and 1989.
- Clinical data and laboratory parameters were reviewed from medical records.
Main Results:
- Radiographic evidence of sinusitis was found in 89 patients; 75 had adequate data for analysis.
- Chronic sinusitis (mucosal thickening) was present in all 75 patients. Acute sinusitis occurred in 10% of patients.
- 67% of patients were symptomatic, while 25% were asymptomatic despite radiographic evidence of active sinusitis.
- The mean CD4 count was 276 cells/mm3, with 43% having counts ≤100 cells/mm3, indicating significant immunocompromise.
Conclusions:
- Sinusitis is frequent in HIV-infected individuals.
- The condition is often asymptomatic and can be recurrent or refractory.
- Sinusitis may be associated with declining immunocompetence in the context of HIV infection.