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Human urinary glycosaminoglycans as accurate method for ovulation detection
A Carranco1, R Reyes, L Huacuja
1División de Biología del Desarrollo, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco.
International Journal of Fertility
|July 1, 1992
Summary
Urinary glycosaminoglycans (GAGs) levels peak at ovulation, correlating with hormonal changes. Measuring urinary GAGs offers a precise method for detecting ovulation, aiding in fertility and reproductive health monitoring.
Area of Science:
- Reproductive Endocrinology
- Biochemistry
Background:
- Glycosaminoglycans (GAGs) are crucial biomolecules involved in various physiological processes.
- Understanding GAGs' role in the menstrual cycle can offer insights into reproductive health.
Purpose of the Study:
- To investigate the pattern of urinary GAGs during normal and hormonally induced menstrual cycles.
- To determine if urinary GAGs can serve as a precise marker for ovulation detection.
Main Methods:
- Monitoring urinary GAGs content throughout the menstrual cycle.
- Correlating GAGs levels with hormonal surges (LH surge) and ovulatory markers (BBT, ultrasound, progesterone).
- Analyzing GAGs composition in urine, identifying major components.
Main Results:
- Urinary GAGs exhibited a distinct peak concentration at ovulation, centered around the LH surge (day 0).
- Hormonally induced cycles showed a significant increase (70%) in GAGs, suggesting hormonal influence.
- Chondroitin sulfate C was identified as the major urinary GAG at ovulation; heparin was absent.
Conclusions:
- Urinary GAGs determination is a precise and reliable method for detecting ovulation.
- The observed correlation suggests GAGs are influenced by hormonal fluctuations during the reproductive cycle.