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Related Experiment Videos

[Immunoglobulin E and its relation to bronchial asthma].

E Spanár, J Cáp, R Pullmann

    Allergie Und Immunologie
    |January 1, 1976
    PubMed
    Summary

    Patients with atopic asthma show significantly higher immunoglobulin E (IgE) levels compared to healthy individuals or those with infectious asthma. Corticosteroid treatment suppressed IgE and cortisol, with levels rising upon withdrawal.

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    Transplantation proceedings·2013

    Area of Science:

    • Immunology
    • Allergy Research
    • Respiratory Medicine

    Context:

    • Asthma bronchiale is a common respiratory condition with varying underlying mechanisms.
    • Atopic asthma is characterized by an allergic response, often associated with elevated immunoglobulin E (IgE).
    • Understanding IgE levels is crucial for diagnosing and managing different asthma phenotypes.

    Purpose:

    • To compare immunoglobulin E (IgE) levels in the blood serum of healthy individuals, patients with infectious asthma, and patients with atopic asthma.
    • To investigate the effect of corticosteroid therapy (Triamcinolone) on IgE and cortisol levels in atopic asthma patients.
    • To assess the reversibility of IgE and cortisol level changes after corticosteroid withdrawal.

    Summary:

    • Radioimmunoassay (Phadebas IgE Test) was used to quantify IgE levels.
    • No significant difference in IgE levels was observed between healthy individuals and those with infectious asthma.
    • Patients with atopic asthma exhibited markedly elevated IgE levels, which decreased with corticosteroid treatment.
    • Corticosteroid therapy also suppressed plasmatic cortisol levels, with both IgE and cortisol increasing after treatment cessation.

    Impact:

    • This study highlights the distinct immunological profile of atopic asthma, characterized by elevated IgE.
    • It demonstrates the efficacy of corticosteroids in suppressing IgE and cortisol levels in atopic asthma.
    • The findings underscore the importance of monitoring IgE and cortisol levels during and after corticosteroid therapy for atopic asthma management.

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