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Related Experiment Videos

Dermatitis caused by dimethyl cyanocarbonimidodithioate.

D Z Hung1, J F Deng, W J Tsai

  • 1Department of Medicine, Veterans General Hospital, Taipei, Taiwan.

Journal of Toxicology. Clinical Toxicology
|January 1, 1992
PubMed
Summary

Dimethyl cyanocarbonimidodithioate exposure caused severe allergic dermatitis resembling erythema multiforme in an occupational setting. Systemic steroid therapy proved beneficial for this cell-mediated allergic skin reaction.

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Area of Science:

  • Occupational Dermatology
  • Toxicology
  • Immunology

Background:

  • Dimethyl cyanocarbonimidodithioate (CAS No. 10191-60-3) is an industrial chemical used in cimetidine synthesis.
  • Limited data exists on its human toxicity, with only an irritant label on storage tanks.
  • Occupational exposure risks are not well-defined.

Observation:

  • A clerk experienced severe dermatitis after accidental bare-handed contact with dimethyl cyanocarbonimidodithioate.
  • Initial symptoms included pruritus, erythema, and vesicles, rapidly progressing to generalized erythema and bullae over 40% of the body.
  • Clinical presentation mimicked erythema multiforme and second-degree burns.

Findings:

  • Laboratory tests revealed elevated serum IgE and lymphocyte activation, indicating a cell-mediated allergic skin reaction.

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  • The patient's condition improved with systemic steroid therapy over two weeks.
  • This case highlights a severe reaction to dimethyl cyanocarbonimidodithioate, similar to reactions seen with ranitidine intermediates.

    • Implications:

    • Dimethyl cyanocarbonimidodithioate can cause severe allergic contact dermatitis in occupational settings.
    • Awareness of this potential hazard is crucial for workers handling the chemical.
    • Prompt diagnosis and systemic steroid treatment are effective management strategies.