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Suppression of T-cell responsiveness during tsetse-transmitted trypanosomiasis in cattle
1International Laboratory for Research on Animal Diseases, Nairobi, Kenya.
Scandinavian Journal of Immunology. Supplement
|January 1, 1992
Abstract:
In the present study, we demonstrate that lymph node cells from cattle infected with T. congolense through tsetse fly challenge were unable to proliferate in vitro following activation with the T-cell mitogen Concanavalin A. This was associated with a simultaneous suppression of interleukin 2 (IL-2) production and interleukin 2 receptor (IL-2R) expression. However, the capacity of the cells to secrete interferon gamma following the mitogenic activation was not affected by the infection.