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Mapping rat brain structures activated during ethanol withdrawal: role of glutamate and NMDA receptors
P F Morgan1, N S Nadi, J Karanian
1Laboratory of Clinical Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Abstract:
Brain structures activated during ethanol withdrawal have been mapped by visualizing c-fos mRNA expression. The regional distribution of c-fos mRNA in brain during ethanol withdrawal can be mimicked by acute injection of N-methyl-D-aspartic acid (NMDA) and is stereospecifically blocked by the NMDA receptor antagonist, MK-801. The findings reveal that the dentate gyrus and piriform cortex are selectively activated during ethanol withdrawal and suggest that this may be mediated by glutamate activation of NMDA receptors.

