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Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase
T Sunazuka1, K Tsuzuki, H Kumagai
1Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
The Journal of Antibiotics
|July 1, 1992
Abstract:
Simple and efficient syntheses of 1233A analogs were developed and the inhibitory activity of the analogs against hydroxymethylglutaryl coenzyme A (HMG-CoA) synthase was determined. Study of the structure-activity relationships revealed that not only the geometry in beta-lactone moiety but also the length of the carbon side chain is important for inhibitory activity against HMG-CoA synthase.