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First prenatal diagnosis of X-linked lymphoproliferative disease
1Center for Human Genetics, Boston University School of Medicine, Massachusetts 02118.
American Journal of Medical Genetics
|September 1, 1992
Abstract:
A family study was performed in order to diagnose X-linked lymphoproliferative (XLP) disease in a fetus. The molecular genetic analysis indicated that the fetus, as well as its healthy 7-year-old brother, inherited XLP. Analysis of immunoglobulin subclasses from the 7-year-old brother supported the DNA-based diagnosis. This is the first XLP family of African descent.