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Somatostatin analogs in the treatment of acromegaly
S W Lamberts1, J C Reubi, E P Krenning
1Department of Medicine, Erasmus University, Rotterdam, The Netherlands.
Endocrinology and Metabolism Clinics of North America
|September 1, 1992
Abstract:
Medical therapy of acromegaly with the somatostatin analog octreotide is very successful. Both clinical symptomatology and hormonal hypersecretion by the growth hormone-secreting pituitary adenomas are controlled, and peripheral IGF-I levels also return to near normal levels. Tumor shrinkage is observed in most patients. Somatostatin analogs can be used after noncurative surgery and for a limited period after radiotherapy, and octreotide pretreatment might improve the outcome of surgery.