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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

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Validation of subjective measures of fatigue after elective operations.

L S Buxton¹, F A Frizelle, B R Parry

¹Department of Kinesiology, University of Otago, Dunedin, New Zealand.

The European Journal of Surgery = Acta Chirurgica

|August 1, 1992

Summary

Postoperative fatigue can be reliably assessed using questionnaires. This study validated questionnaire measures against objective physical indicators, confirming their effectiveness in tracking patient recovery.

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Area of Science:

Surgical Recovery
Patient-Reported Outcomes
Clinical Assessment Tools

Background:

Postoperative fatigue is a common patient experience.
Objective measurement of fatigue can be challenging.
Validated tools are needed to assess patient recovery.

Purpose of the Study:

To determine the feasibility of using questionnaires to evaluate postoperative fatigue.
To validate questionnaire-derived fatigue measures against objective physiological data.

Main Methods:

An open study was conducted at a university hospital.
Twenty-three patients undergoing elective surgery completed a fatigue questionnaire pre- and post-operatively.
Six fatigue measures were validated against body weight, exercise tolerance, and grip strength.

Main Results:

All six questionnaire-based fatigue measures showed significant increases post-surgery.
Fatigue measures demonstrated good correlation with objective parameters like body weight, exercise tolerance, and grip strength.
Sensitivity varied between measures assessing perceived weakness versus tiredness.

Conclusions:

Questionnaires are a reliable method for assessing postoperative fatigue.
Validated patient-reported outcomes can effectively track recovery after surgery.
This approach offers a practical tool for clinicians monitoring surgical patients.